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Research Guide

Understanding Your COA

A Certificate of Analysis — or COA — summarises analytical information associated with a particular product or batch. At 99.9%, transparency starts with being able to connect a product to its available analytical information.

Est. Read 7 MinUpdated Aug 2026Category: Research Resources

Start with the batch number

Before looking at the analytical results, confirm:

Technical Data
BATCH ON VIAL = BATCH ON COA

A test result from another batch does not necessarily establish the characteristics of the batch in your possession.

Purity

You may see a result such as:

Technical Data
PURITY
99.9%

Purity represents the proportion of the analysed material attributed to the target compound under the analytical method used. It should not be confused with dosage, concentration or quantity.

HPLC

HPLC stands for High-Performance Liquid Chromatography. It is an analytical technique used to separate and measure components within a sample.

A chromatogram displays detector response over time. The primary peak generally corresponds to the dominant detected component under the test conditions, while smaller peaks may represent other detected components.

Mass spectrometry

Mass spectrometry provides information about the molecular mass characteristics of a compound. It can be used as part of identity verification by comparing analytical observations with the expected molecular characteristics.

Identity

A COA may state:

Technical Data
IDENTITY
VERIFIED

This indicates that the analytical information used for identity assessment was consistent with the expected compound under the applicable test methodology.

Test date

Always check when testing occurred. Analytical documentation should identify the relevant batch and testing information clearly enough for researchers to understand what was tested.

Release status

Where shown:

Technical Data
RELEASED

indicates that the batch passed the supplier’s applicable release criteria.

What a COA does NOT tell you

A COA should not be interpreted as evidence that a research compound is approved to diagnose, treat, prevent or cure a medical condition. It is analytical documentation — not medical approval.

The 99.9% rule

Before relying on a laboratory document, check:

Technical Data
PRODUCT ✓
BATCH ✓
PURITY ✓
IDENTITY ✓
TEST INFORMATION ✓
STATUS ✓
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